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Regulation of adipogenesis by canonical Wnt signaling cascade. In the presence of Wnt signaling, adipogenesis is inhibited through β-catenin-mediated expression of Wnt target genes. Wnt pathway antagonists, including frizzled-related proteins (sFRPs), Wnt inhibitory factor (WIF-1), and Cerberus and Dickkopfs (Dkk), inhibit Wnt signaling and subsequently stimulate adipogenesis.
