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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Nucl Med Biol. 2010 Oct;37(7):785–794. doi: 10.1016/j.nucmedbio.2010.03.010

Table 2.

Biodistribution of [125I]SGMIB-NZ-1 and [125I]SGMIB-NZ-1 + cold NZ-1 in athymic mice bearing D2159MG xenografts a

Tissue Pecent injected dose per gram
6 h 24 h 48 h
[125I]SGMIB-NZ- [125I]SGMIB-NZ-1 + cold NZ-1 [125I]SGMIB-NZ-1 [125I]SGMIB-NZ-1 + cold NZ-1 [125I]SGMIB-NZ- [125I]SGMIB-NZ-1 + cold NZ-1
Liver 5.92 ± 2.40 5.75 ± 1.27 2.68 ± 0.74 2.89 ± 0.52 1.68 ± 0.57 2.42 ± 0.40
Spleen 4.75 ± 2.34 3.97 ± 0.66 2.00 ± 0.46 2.44 ± 0.48 1.38 ± 0.58 1.77 ± 0.23
Lungs 11.35 ± 5.16 11.27 ± 2.98 5.23 ± 0.97 6.73 ± 0.99 3.67 ± 1.44 5.21 ± 0.91
Heart 4.05 ± 1.22 5.23 ± 0.81 2.56 ± 0.54 3.66 ± 1.06 1.78 ± 0.78 2.47 ± 0.27
Kidneys 4.40 ± 0.70 5.56 ± 0.66 2.61 ± 0.77 3.46 ± 0.71 1.78 ± 0.70 2.76 ± 0.28
Stomach 0.94 ± 0.40 1.20 ± 0.39 0.41 ± 0.19 0.44 ± 0.16 0.28 ± 0.13 0.54 ± 0.12
Small intestine 1.52 ± 0.13 2.31 ± 0.43 0.83 ± 0.21 1.03 ± 0.15 0.64 ± 0.26 0.97 ± 0.09
Large intestine 1.31 ± 0.15 1.62 ± 0.43 0.63 ± 0.17 0.68 ± 0.14 0.45 ± 0.16 0.69 ± 0.18
Thyroid 0.40 ± 0.19 0.54 ± 0.18 0.20± 0.11 0.24 ± 0.10 0.17 ± 0.05 0.24 ± 0.06
Muscle 1.03 ± 0.27 1.05 ± 0.15 0.96 ± 0.18 1.28 ± 0.16 0.67 ± 0.21 0.93 ± 0.10
Blood 15.20 ± 2.39 19.03 ± 2.54 8.35 ± 2.20 12.08 ± 2.29 5.68 ± 2.18 9.13 ± 0.71
Bone 1.41 ± 0.21 1.72 ± 0.40 1.12 ± 0.44 1.33 ± 0.23 0.82 ± 0.21 1.08 ± 0.20
Brain 0.48 ± 0.07 0.60 ± 0.08 0.31 ± 0.10 0.42 ± 0.10 0.23 ± 0.04 0.33 ± 0.12
a

Values are mean %ID/g ± S.D. (n=5) except for thyroid for which %ID/organ is used.