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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Nucl Med Biol. 2010 Oct;37(7):741–750. doi: 10.1016/j.nucmedbio.2010.04.020

Table 1.

Paired-label biodistribution of L8A4 labeled with 177Lu using 1B4M-DTPA and with 125I using SGMIB in athymic mice with subcutaneous U87MG. EGFR human glioma xenografts

Nuclide Tissue Day 1 Day 4 Day 8
177Lu Blood 19.78 ± 2.94 10.75 ± 2.88 1.35 ± 0.94
Liver 8.36 ± 0.74 7.52 ± 2.18 4.16 ± 0.54
Spleen 5.64 ± 1.13 4.62 ± 1.73 2.01 ± 1.01
Kidneys 8.06 ± 1.03 5.34 ± 1.25 2.61 ± 0.32
Lung 6.87 ± 1.61 6.00 ± 3.12 0.93 ± 0.45
Bone 3.58 ± 1.44 2.44 ± 0.71 1.82 ± 0.52
Muscle 1.64 ± 0.08 0.88 ± 0.22 0.30 ± 0.07
Brain 0.58 ± 0.13 0.40 ± 0.12 0.07 ± 0.05
Thyroida 0.50 ± 0.13 0.27 ± 0.07 0.11 ± 0.04
Tumor 31.58 ± 7.24 29.24 ± 6.03 15.27 ± 5.16
125I Blood 18.78 ± 2.24 10.64 ± 2.86 1.29 ± 0.87
Liver 5.11 ± 0.86 2.89 ± 0.75 0.42 ± 0.32
Spleen 4.48 ± 0.72 2.26 ± 0.80 0.28 ± 0.19
Kidneys 4.73 ± 0.68 2.74 ± 0.69 0.39 ± 0.29
Lung 6.81 ± 1.40 4.28 ± 0.78 0.58 ± 0.41
Bone 3.02 ± 0.99 1.53 ± 0.49 0.33 ± 0.18
Muscle 1.66 ± 0.08 0.85 ± 0.19 0.15 ± 0.10
Brain 0.55 ± 0.13 0.40 ± 0.10 0.05 ± 0.04
Thyroida 0.37 ± 0.30 0.31 ± 0.07 0.02 ± 0.03
Tumor 21.64 ± 4.53 9.60 ± 1.72 2.86 ± 0.98

Values presented as percent injected dose per gram tissue (% ID/g), mean ″ standard deviation; five mice per group.

a

Percent injected dose in the thyroid.