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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Nucl Med Biol. 2010 Oct;37(7):741–750. doi: 10.1016/j.nucmedbio.2010.04.020

Table 2.

Paired-label biodistribution of L8A4 labeled with 177Lu using CHX-A″-DTPA and with 125I using SGMIB in athymic mice with subcutaneous U87MG. EGFR human glioma xenografts

Nuclide Tissue Day 1 Day 4 Day 8
177Lu Blood 15.18 ± 3.30 6.10 ± 2.47 0.99 ± 0.71
Liver 8.53 ± 2.39 9.36 ± 3.59 4.45 ± 0.87
Spleen 5.98 ± 1.86 3.97 ± 0.53 1.84 ± 0.70
Kidneys 6.07 ± 1.56 3.96 ± 1.24 2.00 ± 0.37
Lung 5.39 ± 1.28 2.44 ± 0.94 0.56 ± 0.23
Bone 5.95 ± 1.27 6.55 ± 1.77 7.56 ± 1.88
Muscle 1.30 ± 0.44 0.64 ± 0.21 0.19 ± 0.05
Brain 0.46 ± 0.12 0.21 ± 0.08 0.05 ± 0.03
Thyroida 0.44 ± 0.13 0.24 ± 0.07 0.14 ± 0.07
Tumor 36.28 ± 6.60 29.00 ± 7.07 8.67 ± 3.42
125I Blood 16.24 ± 3.73 8.18 ± 3.25 1.50 ± 1.32
Liver 4.43 ± 0.77 2.14 ± 0.86 0.46 ± 0.37
Spleen 3.77 ± 1.43 1.51 ± 0.52 0.35 ± 0.30
Kidneys 3.87 ± 1.03 2.16 ± 1.18 0.42 ± 0.34
Lung 5.70 ± 1.64 2.90 ± 1.30 0.50 ± 0.40
Bone 2.51 ± 0.86 1.24 ± 0.51 0.36 ± 0.27
Muscle 1.37 ± 0.58 1.29 ± 0.49 0.16 ± 0.13
Brain 0.50 ± 0.13 0.28 ± 0.10 0.09 ± 0.09
Thyroida 0.50 ± 0.13 0.27 ± 0.09 0.09 ± 0.02
Tumor 27.56 ± 4.82 13.09 ± 2.97 3.39 ± 2.19

Values presented as percent injected dose per gram tissue (% ID/g), mean ″ standard deviation; five mice per group.

a

Percent injected dose in the thyroid.