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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Nucl Med Biol. 2010 Oct;37(7):741–750. doi: 10.1016/j.nucmedbio.2010.04.020

Table 3.

Paired-label biodistribution of L8A4 labeled with 177Lu using C-DOTA and with 125I using SGMIB in athymic mice with subcutaneous U87MG. EGFR human glioma xenografts

Nuclide Tissue Day 1 Day 4 Day 8
177Lu Blood 10.95 ± 1.53 2.47 ± 1.80 1.33 ± 1.60
Liver 13.00 ± 4.79 9.34 ± 1.71 5.39 ± 2.54
Spleen 5.43 ± 1.50 3.61 ± 1.02 2.47 ± 1.84
Kidneys 4.26 ± 0.70 1.28 ± 0.60 1.22 ± 0.67
Lung 4.21 ± 1.28 0.99 ± 0.70 0.72 ± 0.67
Bone 4.49 ± 0.84 1.21 ± 0.53 2.39 ± 1.55
Muscle 1.32 ± 0.26 0.30 ± 0.14 0.25 ± 0.16
Brain 0.37 ± 0.05 0.22 ± 0.37 0.05 ± 0.04
Thyroida 0.17 ± 0.09 0.04 ± 0.03 0.06 ± 0.05
Tumor 23.52 ± 3.14 12.04 ± 6.29 7.47 ± 6.89
125I Blood 13.93 ± 3.17 8.16 ± 1.08 3.82 ± 3.70
Liver 4.15 ± 0.85 1.78 ± 0.25 1.14 ± 1.07
Spleen 2.89 ± 0.59 1.62 ± 0.18 0.81 ± 0.78
Kidneys 3.47 ± 0.63 1.61 ± 0.36 1.00 ± 0.93
Lung 5.46 ± 1.86 2.49 ± 0.53 1.60 ± 1.50
Bone 2.47 ± 0.21 0.87 ± 0.17 0.57 ± 0.41
Muscle 1.64 ± 0.32 0.59 ± 0.09 0.40 ± 0.32
Brain 0.48 ± 0.08 0.41 ± 0.46 0.13 ± 0.10
Thyroida 0.29 ± 0.11 0.22 ± 0.10 0.18 ± 0.12
Tumor 20.76 ± 5.02 11.24 ± 3.09 7.37 ± 6.27

Values presented as percent injected dose per gram tissue (% ID/g), mean ″ standard deviation; five mice per group.

a

Percent injected dose in the thyroid.