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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Nucl Med Biol. 2010 Oct;37(7):741–750. doi: 10.1016/j.nucmedbio.2010.04.020

Table 4.

Paired-label biodistribution of L8A4 labeled with 177Lu using MeO-DOTA and with 125I using SGMIB in athymic mice with subcutaneous U87MG. EGFR human glioma xenografts

Nuclide Tissue Day 1 Day 4 Day 8
177Lu Blood 15.35 ± 2.41 3.73 ± 2.88 0.70 ± 0.62
Liver 7.88± 1.56 4.67 ± 1.55 2.89 ± 0.71
Spleen 4.53 ± 0.52 2.72 ± 1.00 1.44 ± 0.55
Kidneys 7.04 ± 0.69 3.53 ± 0.88 2.34 ± 0.32
Lung 5.01 ± 1.82 1.34 ± 0.73 0.43 ± 0.27
Bone 2.75 ± 0.40 0.90 ± 0.39 0.82 ± 0.29
Muscle 1.65 ± 0.35 0.46 ± 0.19 0.15 ± 0.08
Brain 0.51 ± 0.12 0.11 ± 0.07 0.04 ± 0.03
Thyroida 0.26 ± 0.13 0.06 ± 0.05 0.02 ± 0.01
Tumor 38.77± 8.55 26.30 ± 9.68 10.37 ± 4.05
125I Blood 15.62 ± 2.32 4.09 ± 3.22 0.81 ± 0.71
Liver 4.07 ± 0.50 0.98 ± 0.71 0.31 ± 0.26
Spleen 2.74 ± 0.49 0.76 ± 0.54 0.22 ± 0.17
Kidneys 3.74 ± 0.57 0.88 ± 0.55 0.25 ± 0.20
Lung 5.16 ± 1.83 1.23 ± 0.80 0.34 ± 0.29
Bone 2.61 ± 0.38 0.63 ± 0.38 0.26 ± 0.16
Muscle 1.67 ± 0.40 0.41 ± 0.20 0.11 ± 0.08
Brain 0.52 ± 0.11 0.11 ± 0.07 0.03 ± 0.03
Thyroida 0.31 ± 0.13 0.12 ± 0.06 0.08 ± 0.02
Tumor 25.19 ± 4.77 7.52 ± 3.66 2.22 ± 1.44

Values presented as percent injected dose per gram tissue (% ID/g), mean ″ standard deviation; five mice per group.

a

Percent injected dose in the thyroid.