Table 5.
Tumor-to-normal tissue ratios of radioactivity in athymic mice bearing subcutaneous U87. EGFR human glioma xenografts 3 days after injection of L8A4 mAb labeled with 177Lu using MeO-DOTA and 125I using SGMIB
| Tissue | Lu MeO-DOTA | I SGMIB |
|---|---|---|
| Liver | 7.8 ″ 4.1 | 10.4 ″ 2.6 |
| Spleen | 14.6 ″ 4.6 | 14.9 ″ 3.9 |
| Lungs | 25.4 ″ 3.8 | 7.6 ″ 2.5 |
| Heart | 39.4 ″ 8.6 | 10.8 ″ 2.2 |
| Kidney | 9.4 ″ 4.1 | 11.0 ″ 2.4 |
| Stomach | 214 ″ 47 | 72.1 ″ 17.1 |
| Small Intestine | 84.1 ″ 21.6 | 33.0 ″ 8.5 |
| Large Intestine | 96.8 ″ 37.7 | 37.7 ″ 13.7 |
| Blood | 10.8 ″ 3.3 | 2.9 ″ 0.7 |
| Muscle | 69.6 ″ 22.0 | 21.4 ″ 6.9 |
| Bone | 35.9 ″ 9.7 | 15.4 ″ 4.0 |
| Brain | 350 ″ 50 | 88.8 ″ 17.4 |