Table 1. Initial screening of antibiotics in a mouse model (Trypanosoma congolense strain IL3343).
Treatment | Cured | Median PP (days) | 95% confidence intervals |
Untreated control | 0/6 | 5,41 | 4,10–7,16 |
Penicilline G (100mg/kg) | 0/6 | 5,79 | 4,38–7,77 |
Nalidixic acid (175mg/kg) | 0/6 | 6,29 | 4,76–8,32 |
Tetracycline (125mg/kg) | 0/6 | 6,80 | 5,14–8,99 |
Oxytetracycline (125mg/kg) | 0/6 | 5,06 | 3,83–6,69 |
Enrofloxacine (40mg/kg) | 0/6 | 5,22 | 3,95–6,90 |
ISM (1mg/kg) | 0/6 | 16,29 | 12,32–21,53 |
ISM/Penicilline G (*) | 0/6 | 12,27 | 9,28–16,22 |
ISM/Nalidixic acid | 0/6 | 16,73 | 12,66–22,13 |
ISM/Tetracycline | 4/6 | 51.96 | 38.01–71.05 |
ISM/Oxytetracycline | 3/6 | 39.1 | 29.16–52.43 |
ISM/Enrofloxacine | N.T. | - | - |
(*) ISM at 1mg/kg combined to the antibiotic at the dose used alone; N.T.: Not Tested.