Skip to main content
. 2010 Sep 28;4(9):e828. doi: 10.1371/journal.pntd.0000828

Table 1. Initial screening of antibiotics in a mouse model (Trypanosoma congolense strain IL3343).

Treatment Cured Median PP (days) 95% confidence intervals
Untreated control 0/6 5,41 4,10–7,16
Penicilline G (100mg/kg) 0/6 5,79 4,38–7,77
Nalidixic acid (175mg/kg) 0/6 6,29 4,76–8,32
Tetracycline (125mg/kg) 0/6 6,80 5,14–8,99
Oxytetracycline (125mg/kg) 0/6 5,06 3,83–6,69
Enrofloxacine (40mg/kg) 0/6 5,22 3,95–6,90
ISM (1mg/kg) 0/6 16,29 12,32–21,53
ISM/Penicilline G (*) 0/6 12,27 9,28–16,22
ISM/Nalidixic acid 0/6 16,73 12,66–22,13
ISM/Tetracycline 4/6 51.96 38.01–71.05
ISM/Oxytetracycline 3/6 39.1 29.16–52.43
ISM/Enrofloxacine N.T. - -

(*) ISM at 1mg/kg combined to the antibiotic at the dose used alone; N.T.: Not Tested.