List 2.

Exclusionary criteria for the Pediatric Cardiomyopathy Registry

• Endocrine disease known to cause heart muscle disease (including infants of diabetic mothers).

• A history of rheumatic fever.

• Toxic exposures known to cause heart muscle disease (e.g., anthracyclines, mediastinal radiation, iron overload, or heavy metal exposure).

• HIV infection or born to an HIV positive mother.

• Kawasaki disease.

• Congenital heart defects unassociated with malformation syndromes (e.g., valvar heart disease or congenital coronary artery malformations).

• Immunologic disease.

• Invasive cardiothoracic procedures or major surgery during the preceding month except those specifically related to cardiomyopathy including LVAD, ECMO and AICD placement.

• Uremia, active or chronic.

• Abnormal ventricular size or function that can be attributed to intense physical training or chronic anemia.

• Chronic arrhythmia unless there are studies documenting inclusion criteria prior to the onset of arrhythmia (except a patient with chronic arrhythmia, subsequently ablated, whose cardiomyopathy persists after two months is not to be excluded).

• Malignancy.

• Pulmonary parenchymal or vascular disease (e.g., cystic fibrosis, cor pulmonale, or pulmonary hypertension).

• Ischemic coronary vascular disease.

• Age less than 18 years.

• Association with drugs known to cause hypertrophy (e.g., growth hormone, corticosteroids or cocaine)

• Left ventricular assist device; extracorporeal membrane oxygenation; automatic implantable cardioverter defibrillator.