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. 2010 Mar 16;2010:947816. doi: 10.1155/2010/947816

Figure 7.

Figure 7

Prevention of BM failure following IF gene transfer into mice with BM aplasia. (a) FancC-EGFP transgene expression in peripheral blood cells of preconditioned IF-injected wild type (WT), FancC −/−, and FancA −/− mice that received chronic MMC treatments at 7 weeks following IF-injection as a function of time. The arrow represents the start of weekly MMC injections (0.3 mg/kg). Each dot represents the FancC-EGFP expression of an individual IF-injected mouse. Horizontal line: mean value. (b) Representative cytometric profiles of FancC-EGFP expression in peripheral blood cell lineages from FancC −/− preconditioned IF-injected mice at 15 weeks following weekly MMC treatment. (c) Survival of preconditioned IF-injected FancC −/− (n = 6) and FancA −/− (n = 4) mice following MMC treatments. Control FancC −/− mice represent uninjected mice treated weakly with MMC (n = 22). (d) Representative histological appearances of the sternum from preconditioned and IF-injected mice at four months following IF injections (no treatment) and at 15 weeks following weekly MMC treatment (+ MMC). Hematoxylin-eosin staining: original magnification 200×.