Table 1.
Demographic features of affected individuals
| Samples | Cases | Controls | Average Age at Onset |
EDSS % | Disease Course % | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <3 | 3 to <6 | ≥6 | Unkn | RR | SP | PP | PR | Unkn | ||||
| WTCCC nsSNP screen | 975 | 1466 | 30.3 | 27.2 | 24.3 | 48.1 | 0.4 | 54.6 | 32.0 | 13.0 | 0.0 | 0.4 |
| Replication Stage 1 | 1038 | 1379 | ||||||||||
| UK1 | 369 | 764 | 32.3 | 35.8 | 17.6 | 43.6 | 3.0 | 54.2 | 26.3 | 15.5 | 0.0 | 3.8 |
| US | 669 | 615 | 33.9 | 53.0 | 23.8 | 23.3 | 0 | 49.9 | 17.9 | 10.2 | 3.0 | 19.0 |
| Replication Stage 2 | 2406 | 1216 | ||||||||||
| Australia | 159 | 120 | 34.4 | 33.8 | 38.9 | 26.8 | 0.6 | 63.9 | 18.4 | 5.1 | 2.5 | 10.1 |
| Italy | 829 | 635 | 32.5 | 47.1 | 25.2 | 16.6 | 11.2 | 69.0 | 11.3 | 8.7 | 1.4 | 9.6 |
| UK2 | 1418 | 461 | 30.0 | 28.2 | 27.3 | 42.5 | 2.0 | 57.9 | 31.0 | 8.8 | 0.0 | 2.3 |
EDSS = Expanded Disability Status Scale; RR = Relapse Remitting; SP = Secondary Progressive; PP = Primary Progressive; PR – Progressive Relapsing; Unkn = Unknown