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. 2010 Oct;136(4):367–387. doi: 10.1085/jgp.201010430

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© 2010 Bailey et al.

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Figure 11. — PCMBS slows transition k₅₃, as determined through the constrained version of the model. (A) Representative activation and deactivation records fit with two variations of the model. The dashed line represents the variation that allowed parameters k₁₂, k₂₁, k₂₃, k₃₂, k₃₅, and k₅₃ to be free, and the solid line represents the variation that held parameters k₁₂, k₂₁, k₂₃, k₃₂, and k₃₅ to k_(-PCMBS) values; k₅₃ is the only free parameter, see Results for details. As noted in the previous figure, the Ca²⁺-dependent rate constants were assumed to have a nonlinear dependence on Ca²⁺ concentration, k = A · [Ca]/(B + [Ca]). The colors refer to the different Ca²⁺ concentrations, with red representing 0.5, blue 0.7, green 1.0, and black 10 μM Ca²⁺. (B) Gating scheme detailing that parameter k₅₃ is modulated by PCMBS, as determined through the constrained version of the model.