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. 2010 Oct;136(4):367–387. doi: 10.1085/jgp.201010430

Figure 8.

Figure 8.

PCMBS modulates C277A channel kinetics in a manner similar to the WT channel. Activation and deactivation kinetics were estimated with Ca2+ jump experiments using Ca2+i concentrations (A) 0.5, (B) 0.7, (C) 1.0, and (D) 10 µM in the absence (black trace) and presence (red trace) of PCMBS as described in Fig. 4. Activation (E) and deactivation (F) rates were estimated by fitting activation and deactivation records with an exponential function and reported as a time constant (τ-on and τ-off) in the absence (▴) and presence (▵) of PCMBS, see also Table I.