Table I.

Exponential fits comparing the activation and deactivation kinetics of KCa3.1

Channel	[Ca2+]i	On	Off	n	PCMBS
					On	Off	n
	μM	ms	ms		ms	ms
KCa3.1 (paired)	0.5	224 ± 22	61 ± 5	13	337 ± 29	402 ± 31	13
	0.7	185 ± 11	60 ± 5	13	250 ± 14	414 ± 30	13
	1.0	147 ± 9	65 ± 4	13	224 ± 12	428 ± 30	13
	10	123 ± 11	59 ± 4	13	206 ± 13	411 ± 34	13
KCa3.1 C276A	0.5	211 ± 20	48 ± 4	7	191 ± 12	60 ± 8	7
	0.7	186 ± 15	46 ± 4	7	154 ± 13	57 ± 6	7
	1.0	142 ± 15	56 ± 3	7	134 ± 12	61 ± 6	7
	10	120 ± 11	43 ± 3	7	103 ± 6	59 ± 6	7
KCa3.1 C277A	0.5	244 ± 10	54 ± 6	6	318 ± 20	377 ± 45	5
	0.7	186 ± 9	59 ± 6	6	262 ± 18	336 ± 46	5
	1.0	152 ± 8	59 ± 5	6	223 ± 19	365 ± 44	5
	10	129 ± 12	59 ± 7	6	194 ± 14	332 ± 39	5
KCa3.1	0.5	209 ± 9	57 ± 2	51
	0.7	170 ± 5	57 ± 2	51
	1.0	141 ± 5	59 ± 2	51
	10	114 ± 5	56 ± 2	51
KCa3.1 L281W	0.5	149 ± 12	186 ± 11	23	175 ± 20	267 ± 20	8
	0.7	130 ± 9	202 ± 11	23	142 ± 17	278 ± 24	8
	1.0	119 ± 10	198 ± 9	23	119 ± 13	293 ± 27	8
	10	92 ± 7	197 ± 9	23	100 ± 10	288 ± 27	8
KCa3.1 V282W	0.5	161 ± 11	59 ± 3	13
	0.7	131 ± 8	59 ± 2	13
	1.0	113 ± 8	59 ± 3	13
	10	84 ± 5	58 ± 3	13

Time constants (τ) from single exponential fits to channel activation or deactivation records from the four [Ca²⁺]_i concentrations examined.