Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Sep 27;207(10):2049–2052. doi: 10.1084/jem.20101748

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2010 Sun

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 1. — Education and re-education of NK cells. The figure depicts the “education” of developing NK cells in different bone marrow environments (left) and the experimental “re-education” of mature NK cells in different peripheral environments (right). (A) Immature NK cells expressing inhibitory receptors that engage MHC class I become responsive mature effector cells. (B) Immature NK cells expressing inhibitory receptors that do not engage MHC class I become anergic cells. (C) Immature NK cells lacking inhibitory receptors that can engage MHC class I also become anergic cells. (D) Mature responsive NK cells that are adoptively transferred into a MHC class I–deficient environment become anergic. (E) Mature anergic NK cells (expressing inhibitory receptors for MHC class I) that are adoptively transferred into a MHC class I–sufficient setting become responsive. (F) During viral infection and inflammation, mature anergic NK cells (lacking inhibitory receptors for MHC class I) become activated and hyperresponsive effector cells.