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. 2010 Sep 27;207(10):2187–2194. doi: 10.1084/jem.20100643

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© 2010 Sakuishi et al.

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Figure 4. — Proliferation and cell cycle entry in TILs from CT26 tumor-bearing mice. TILs were harvested from CT26 tumor-bearing mice and stimulated with 1 µg/ml of anti-CD3 before staining with antibodies against CD8, Tim-3, PD-1, and Ki-67 and TO-PRO-3–iodide. (A) Expression of Ki-67 and TO-PRO-3 staining in CD8⁺ TILs showing the different phases of the cell cycle: G0, G1, and S→M. Data shown are representative of six independent analyses. (B) Ratio of Tim-3⁺PD-1⁺ to Tim-3⁻PD-1⁺ TILs (n = 6) in different phases of cell cycle. *, P < 0.05, one-way ANOVA and Tukey’s multiple comparison test. n = 6. Error bars represent SEM.