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. 2010 Sep 27;207(10):2089–2096. doi: 10.1084/jem.20100734

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© 2010 Phythian-Adams et al.

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Figure 3. — CD11c depletion during schistosome infection impairs the liver Th2 response. CD11c.DOG mice were treated daily with PBS (squares) or DTx (triangles) from day 28 to 39 of S. mansoni infection. Naive (black symbols) and infected (gray symbols) mice were assessed for liver CD11c^HiMHCII⁺ cell depletion on day 40 (A and B), and liver cells from naive or infected PBS (white or black bars)- or DTx (gray bars)-treated mice cultured for 72 h with SEA or medium alone. The supernatants were collected, and cytokine production was assessed by ELISA (C and D). Liver CD4⁺ T cell IL-4 production by naive (black symbols) or infected (gray symbols) mice was also assessed by intracellular cytokine staining (E and F). One of three (A and C–F) experiments, or combined data from three experiments (B). Error bars are mean ± SEM of four to seven mice/group, with liver cells combined in groups where cell numbers were restrictive.