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. 2010 Sep 27;207(10):2225–2237. doi: 10.1084/jem.20092712

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© 2010 Guo et al.

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Figure 1. — Chromatin-binding IgG antibodies in B6.Nba2 Tdt^−/− Igh^+/− Igk^+/− mice. (A) Serum titers of IgG anti-chromatin antibodies from B6.Nba2 Tdt^−/− Igh^+/− Igk^+/− mice (8–10 mo old). Red line, representative serum from a nonautoimmune C57BL/6 mouse. Standard errors are shown. (B) Chromatin binding assay with purified monoclonal antibodies generated from a spontaneously autoimmune B6.Nba2 Tdt^−/− Igh^+/− Igk^+/− mouse (female, 12 mo old). A prototypical ANA, 3H9/Vκ4, is shown in red. Bound antibodies were detected in a solid-phase europium (Eu³⁺)-based fluoroimmunometric assay (as counts per second). The figure shows one of two experiments with similar results.