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. 2010 Sep 27;207(10):2225–2237. doi: 10.1084/jem.20092712

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© 2010 Guo et al.

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Figure 2. — HCDR3 sequences for clones subjected to mutation-reversion analysis. Germline-encoded D_H sequences are shown above and germline-encoded V_H and J_H sequences are shown below hybridoma (shaded) sequences. Somatic mutations are underlined. The blue lowercase t in J6.1 is a templated nucleotide (P element) added during V_H(D)J_H recombination. In lineage #4, somatic mutations that eliminated Arg codons are explicitly indicated for both members.