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. 2010 Sep 27;207(10):2271–2281. doi: 10.1084/jem.20092401

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© 2010 Kranich et al.

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Figure 2. — Histopathological analysis of terminal Mfge8^−/− brains. (A) Astroglia proliferation was analyzed by GFAP staining. (B) Microglial activation was visualized by IBA1 staining. (C) TUNEL staining on cerebellar cryosection of i.c. inoculated B6.129-Mfge8^−/− (n = 5) and B6.129-Mfge8^+/+ mice (n = 7). Sections were counterstained with DAPI. Bar graph shows quantitation of TUNEL⁺ cells from at least three cerebellar areas per mouse. Number of TUNEL⁺ cells was normalized against the number of DAPI⁺ nuclei. Graph shows percentage of TUNEL⁺ cells per area ± SD (*, P = 0.023; Student’s t test). Results summarize at least five independent experiments. Bars: (A and C) 100 µm; (B) 200 µm.