Table 1. Median values of potential predictors of the splicing outcome.
Group | Mutation outcome | Number of sequences | Exon length | PESS density | NN splice density of 5′ss | SF2/ASF score density | FAS-ESS density (hex2) | NI score density | EIE score density | IIE score density |
---|---|---|---|---|---|---|---|---|---|---|
Training set | EXSK | 238 | 116 | 1.22 | 0.03 | 10.02 | 3.46 | 30.31 | 440.83 | 313.16 |
CR-E | 163 | 154 | 0.65 | 0.14 | 12.36 | 3.06 | 36.86 | 460.18 | 274.81 | |
Test set | EXSK | 59 | 102 | 1.01 | 0.02 | 10.52 | 3.24 | 31.69 | 449.46 | 316.58 |
CR-E | 41 | 131 | 0.69 | 0.10 | 12.23 | 3.45 | 37.41 | 431.27 | 251.75 | |
All | EXSK | 297 | 111 | 1.09 | 0.03 | 10.12 | 3.42 | 31.19 | 443.11 | 313.70 |
CR-E | 204 | 148 | 0.65 | 0.14 | 12.30 | 3.08 | 37.29 | 453.41 | 273.06 |
Abbreviations: EXSK, exon skipping; CR-E, cryptic splice-site activation.
Predictor variables are defined in the text.