Table 2A. Genotype frequencies comparison between ET patients and controls according to the country and to family history.
| Patients | Genotype frequencies | Statistical comparisona | P-value (χ2) | P-value correctedb | ||
|---|---|---|---|---|---|---|
| AA (Ser9Ser) (%) | AG (Ser9Gly) (%) | GG (Gly9Gly) (%) | ||||
| Controls (German/Danish/French) (1) | 248 (47) | 226 (43) | 54 (10) | — | — | |
| All ET (German/Danish/French) (2) | 131 (44) | 136 (45) | 32 (11) | (1)–(2) | 0.68 | |
| German/Danish/French ET without family history (3) | 50 (52) | 37 (38) | 10 (10) | (1)–(3) | 0.68 | |
| German/Danish/French ET with family history (4) | 81 (40) | 99 (49) | 22 (11) | (1)–(4) | 0.24 | |
| (3)–(4) | 0.16 | |||||
| German ET with family history (5) | 62 (46) | 59 (44) | 14 (10) | — | — | |
| German controls (6) | 145 (47) | 131 (42) | 35 (11) | (5)–(6) | 0.94 | |
| French ET with family history (7) | 12 (25) | 32 (65) | 5 (10) | — | — | |
| French controls (8) | 75 (45) | 74 (45) | 16 (10) | (7)–(8) | 0.0262 | 0.16b |
Genotypes in both patients and controls were in Hardy–Weinberg equilibrium.
a
Statistical comparison of the different numbered case/control groups.
b
Correction for multiple testing (six tests)
Bold values represents P-value <0.05