Table 2B. Allele frequencies comparison between ET patients and controls according to the country and family history.
| Patients | Allele frequencies | Statistical comparisona | P-value (χ2) | P-value correctedb | |
|---|---|---|---|---|---|
| A (%) | G (%) | ||||
| Controls (German/Danish/French) (1) | 722 (68) | 334 (32) | — | — | |
| All ET (German/Danish/French) (2) | 398 (67) | 200 (33) | (1)–(2) | 0.45 | |
| German/Danish/French ET without family history (3) | 137 (71) | 57 (29) | (1)–(3) | 0.54 | |
| German/Danish/French ET with family history (4) | 261 (65) | 143 (35) | (1)–(4) | 0.17 | |
| (3)–(4) | |||||
| German ET with family history (5) | 183 (68) | 87 (32) | — | — | |
| German controls (6) | 421 (68) | 201 (32) | (5)–(6) | 0.97 | |
| French ET with family history (7) | 56 (57) | 42 (43) | — | — | |
| French controls (8) | 224 (68) | 106 (32) | (7)–(8) | 0.046 | 0.39 |
Genotypes in both patients and controls were in Hardy–Weinberg equilibrium.
a
Statistical comparison of the different numbered case/control groups.
b
Correction for multiple testing (six tests).