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. 2010 Sep 22;30(38):12844–12855. doi: 10.1523/JNEUROSCI.2437-10.2010

Figure 4.

Figure 4.

The inhibitory effect of TNFα on sIPSCs in spinal dorsal horn was mediated by the activation of TNFR1 but not TNFR2. A, sIPSCs recorded from a spinal lamina II neuron before (a) and after (b) the application of TNFα when the slice was preincubated with TNFR1 antibody (Ab) to neutralizing TNFR1; c, frequency of sIPSCs as a function of the recording time in the representative neuron in a and b. Frequency was measured every 10 s. B, sIPSCs recorded from a spinal lamina II neuron before (a) and after (b) the application of TNFα when the slice was preincubated with TNFR2 antibody to neutralizing TNFR2; c, frequency of sIPSCs as a function of the recording time in the representative neuron in a and b. Frequency was measured every 10 s. C, Averaged data showed that neutralizing TNFR1 (n = 13) but not TNFR2 (n = 11) prevented the inhibitory effect of TNFα on sIPSCs. **p < 0.01 compared with baseline before application of TNFα (Student's paired t test).