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. 2010 Sep 22;30(38):12844–12855. doi: 10.1523/JNEUROSCI.2437-10.2010

Figure 8.

Figure 8.

TNFα-induced inhibition of spinal inhibitory synaptic transmission is mediated by the activation of p38 MAPK. A, The inhibitory effect of TNFα on sIPSCs was prevented by blocking the activation of p38. sIPSCs recorded from a spinal lamina II neuron before (a) and after (b) the application of TNFα when the slice was preincubated with SB202190, a p38 antagonist; c, frequency of sIPSCs as a function of the recording time in the representative neuron in a and b. B, When the spinal slice was preincubated with SB202474, a p38 blocker inactive analog, application of TNFα significantly decreased the frequency of sIPSCs. Recordings of sIPSCs from a spinal lamina II neuron before (a) and after (b) the application of TNFα; c, frequency of sIPSCs as a function of the recording time in the representative neuron in a and b. Frequency was measured every 10 s in both A and B. C, Averaged data showed the percentage change of the frequency of sIPSCs after the application of TNFα when the slices were preincubated with SB202190 (n = 15) or SB202474 (n = 5). **p < 0.01 compared with baseline before application of TNFα (Student's paired t test).