Table IV.

Correlation of the CCL2 gene polymorphisms with lung function^a

Polymorphism	Age	Age of Diagnosis	Rate of Decline in FEV1 (%/Year)	Rate of Decline in DLCO (%/Year)
A(−2578)G
AA	49.8 ± 0.9 (109)	39.8 ± 0.8 (105)b	3.6 ± 0.4 (99)c	3.7 ± 0.4 (99)d
AG	51.5 ± 1.3 (73)	41.6 ± 1.3 (74)	1.9 ± 0.4 (71)	2.6 ± 0.4 (71)
GG	51.9 ± 2.3 (7)	46.6 ± 2.1 (7)	3.3 ± 2.0 (7)	2.4 ± 0.4 (7)
A(−2136)T
AA	51.1 ± 0.9 (133)	41.1 ± 0.8 (129)	2.7 ± 0.4 (121)	2.9 ± 0.3 (121)
AT	49.3 ± 1.3 (49)	40.2 ± 1.3 (51)	3.3 ± 0.6 (50)	4.1 ± 0.6 (50)
TT	49.0 ± 4.0 (6)	39.0 ± 4.2 (6)	2.1 ± 0.5 (6)	2.8 ± 0.4 (6)

^aLinear regression analyses (SPSS) were performed to assess the relationship between the phenotypes and CCL2 genotypes within the LAM population. Ages were as of 2005. Data are means ± SEM (no. of patients).

^bp = 0.054.

^cp = 0.028.

^dp = 0.058.