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EC50 values obtained for MrgD agonists. Data represents mean ± standard deviation from 2–6 independent experiments.
| Ligand | EC50 in μM | |
|---|---|---|
| Human MrgD | Rat MrgD | |
| Beta-alanine | 3.76 ± 1.27 | 3.77 ± 0.87 |
| GABA | 53 ± 26 | 49.8 ± 1.5 |
| Glycine | >100 | >100 |
| Gabapentin | No effect | No effect |
| Pregabalin | No effect | No effect |
