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. Author manuscript; available in PMC: 2011 Oct 8.
Published in final edited form as: Brain Res. 2010 Jul 30;1355:207–213. doi: 10.1016/j.brainres.2010.07.088

Table 1.

CTZ induced dose-dependent seizure behavior in rats

Treatment DMSO CTZ
 DIZ+CTZ
0.25μmol 0.5μmol 0.75μmol
n 8 5 4 14 5
Seizure number
    Stage II - (0/8) - (0/5) 15 (1/4) 3.8±1.4 (10/14)* 3 (1/5)
    Stage III - (0/8) 5 (1/5) 2.7±1.7 (3/4) 6.9±2.4 (12/14)* 1 (1/5)#
    Stage IV V - (0/8) - (0/5) 1 (1/4) 3.0±0.8 (10/14)** - (0/5)#
 
Seizure duration (s)
    Stage II - (0/8) - (0/5) 505 (1/4) 95.9±42.5 (10/14)
    Stage III - (0/8) 39 (1/5) 29.7±17.2 (3/4) 63.2±28.6 (12/14)*
    Stage IV V - (0/8) - (0/5) 12.0 (1/4) 83.5±36.8 (10/14)*
 
Seizure score 0.3±0.2 0.6±0.6 2.5±0.9 3.9±0.4** 0.6±0.6##

Group data on CTZ dose dependent induced seizure behavior number, siezure duration and seizure score, in compare with DMSO control and anticonvulsant drug diazepam pretreatment.

*

P<0.05

**

P<0.005 in compare with DMSO control

#

P<0.05

##

P<0.005 in compare with CTZ 0.75 μmol group. (the blankets in the table indicate the number of rats responded to the drug verses number of rats tested)