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Hormonal regulation of germ cell nest breakdown. (A) Germ cell nests breakdown giving rise to primordial follicles. (B) Increased activin (act) signaling within neonatal mouse ovaries leads to a higher number of primordial follicles compared with controls. (C) Increased estradiol (E2) signaling within neonatal mouse ovaries downregulates activin expression and results in multi-oocytic follicle (MOF) formation.
