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. 2010 Sep 1;120(10):3713–3721. doi: 10.1172/JCI40440

Figure 5. Normalized β cell mass is mediated by improved survival in Pcif1+/gtPdx1+/– mice.

Figure 5

(A) Apoptosis measured by quantifying insulin- and TUNEL-copositive cells. (B) β Cell replication measured by quantifying insulin and BrdU double positive cells. (C) β Cell size calculated by dividing insulin-positive islet area by the number of DAPI-stained nuclei counted within that area. All morphometric analyses performed on pancreas sections from 16-week-old male mice. n = 5–8 per group; *P < 0.05, **P < 0.01 compared with wild-type.