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. 2010 Sep 27;120(10):3466–3479. doi: 10.1172/JCI42845

Figure 4. Lipolysis inhibition through dietary manipulation limits ATM accumulation during early weight loss.

Figure 4

A caloric restriction protocol was used to induce weight loss with lower rates of lipolysis compared with caloric restriction of mice on a high-fat diet. High-fat diet–induced obese mice were fed 70% of their ad libitum caloric intake for 3 days in the form of either a diet high in carbohydrate or fat content. (A) Serum FFA in mice during weight loss induced by caloric restriction on a diet high in either fat or carbohydrate content. n = 5–6 mice/group. (B) Perigonadal adipose tissue sections from mice during weight loss induced by a diet high in fat (left panel) or high in carbohydrate content (right panel). Arrows indicate ATMs. Scale bars: 50 μm. (C) Macrophages as a percentage of all cells in perigonadal adipose tissue from mice during weight loss induced by caloric restriction on a diet high in either fat or carbohydrate content. n = 5–6 mice/group. *P < 0.05, versus calorie restriction on HFD. All data are represented as mean ± SD.