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. 2010 Sep 27;120(10):3466–3479. doi: 10.1172/JCI42845

Figure 5. ATGL/PNPLA2 deficiency limits ATM accumulation during fasting.

Figure 5

(A) Immunohistochemical staining of F4/80-expressing (EMR1) macrophages in perigonadal adipose tissue sections from Atgl+/+ (top panel) and Atgl–/– (lower panel) mice that were either ad libitum fed (left) or fasted (right). Arrows indicate ATMs. Scale bars: 100 μm. (B) Macrophages as a percentage of all cells in lean ad libitum–fed Atgl+/+ and fasted Atgl–/– mice. n = 4–5 mice/group. ***P < 0.001, versus ad libitum fed. (C) Expression of macrophage-specific genes in perigonadal adipose tissue of lean ad libitum–fed and fasted Atgl–/– mice. n = 4–5 mice/group. All data are represented as mean ± SD.