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An essential role for FAK Tyr397 phosphorylation in tumor cell invasion. A: AGS cells were infected with adenoviruses harboring wild-type FAK, the Y397F mutant, or FRNK and then subjected to tumor invasion assays using matrigel transwells. B: In-gelatin zymography assays were conducted to detect the MMP2 activity of the cells as described in the Materials and Methods section. The mean ± SD from at least three experiments is shown. *P < 0.05; **P < 0.01 as compared with GFP controls.
