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Enhanced expression of mRNA for various cytokines by primed CD4+ T cells cocultured with AM from naïve animals, chronically challenged animals, or animals in which an acute exacerbation had been induced: A: IL-4, B: IL-5, C: IL-6, and D: IL-13. Data are the mean ± SEM (n = 3 samples per group) fold change relative to naïve AM. Significant differences relative to naïve AM are shown as **P < 0.01 and ***P < 0.001.
