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. 2010 Oct;177(4):1657–1664. doi: 10.2353/ajpath.2010.100019

Figure 4.

Figure 4

Inhibition of the enhanced expression of cytokine mRNA by primed CD4+ T cells, as a result of preincubation of cocultured AM from an acute exacerbation with CTLA-4 Fc chimera to prevent costimulation via CD80/86: A: IL-4, B: IL-5, C: IL-6, and D: IL-13. Data are the mean ± SEM (n = 6 samples per group) fold change relative to naïve AM. Significant differences relative to naïve AM are shown as *P < 0.05 and **P < 0.01; relative to non–CTLA-4-treated cultures are shown as †P < 0.05 and ††P < 0.01.