Figure 6.

Fibrosis in regenerating TA muscle of TWEAK-KO and TWEAK-Tg mice. A: Muscle sections prepared from TA muscle ten days post CTX injection were stained with Sirius red dye. Representative photomicrographs show that the level of fibrosis is reduced in regenerating TA muscle of TWEAK-KO mice and increased in TWEAK-Tg mice compared with CTX-injected TA muscle of the corresponding wild-type mice. B: Transcript levels of collagen I measured by QRT-PCR in TA muscle ten days post CTX injection were comparable in wild-type and TWEAK-KO mice but were significantly increased in TWEAK-Tg mice compared with littermate wild-type mice. *P < 0.05, values significantly different form wild-type mice. WT, wild-type.