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. 2010 Oct;177(4):1812–1822. doi: 10.2353/ajpath.2010.100173

Figure 5.

Figure 5

Expression analysis of markers of differentiation in liver after long-term DDC (150 days). A: Representative photomicrographs from two WT and two TG mice after long-term DDC exposure for AFP and Trop-2 staining. Whereas AFP-positive cells (arrows) are periportal in WT livers, they are panzonal in TG livers. WT livers show Trop-2-positive reactive ductules (white arrowhead) and periportal hepatocytes (arrows), whereas TG livers display Trop-2-positive ductules only (white arrowhead). Original magnification, ×200. B: Representative photomicrographs for CK19 show only bile ducts to be positive (arrows) in WT and TG livers. HNF1β immunohistochemistry shows nuclear expression in atypical ductules (white arrowhead) and periportal hepatocytes (arrows) in WT livers but only in reactive ductules (white arrowhead) in TG livers after long-term DDC treatment. Original magnification, ×200.