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. 2010 Oct;177(4):1977–1988. doi: 10.2353/ajpath.2010.100346

Figure 2.

Figure 2

Accelerated motor phenotypes in bigenic PS19;PDAPP mice with reductions in body weight. A: Cross-sectional body weights of WT, PDAPP, PS19, and PS19;PDAPP Tg female mice at 4 and 11 months of age. Bigenic PS19;PDAPP display a more consistent reduction in body weight when compared with monogenic PS19 mice. Additionally, WT and PDAPP mice display significant increases in body weight (*P < 0.05) with age as expected. n = 18 for wild type, n = 5–9 for PDAPP, n = 7–8 for PS19, n = 8–9 for PS19;PDAPP. B: Percentage of female Tg mice displaying motor phenotypes that include paresis, paralysis, and hunchback posture. Mice that display any of these three phenotypes were given a score of 1, whereas mice lacking all three phenotypes were scored as 0. Pie chart represents percentage of mice with a motor score of 1 over two time points (4 and 11 months) and between two Tg mice, that is, PS19, and PS19;PDAPP. n = 9 for PS19, n = 8–9 for PS19;PDAPP. C and D: Comparisons of male and female bigenic PS19;PDAPP mice by cross-sectional body weight (C) and motor phenotype (D) at 4 and 11 months of age. Bigenic male mice display larger decreases in body weight and greater percentages of mice with a motor phenotype. n = 6–8 for PS19;PDAPP males, n = 8–9 for PS19;PDAPP females. E and F: Kaplan–Meier Survival Curves comparing female (E) and male (F) PS19 and bigenic PS19;PDAPP mice. Bigenic mice demonstrate a statistically significant (P = 0.0492) increase in premature death rate with a median survival of 12 months for females (versus 13 months for female PS19 monogenic) and 10 months for males (versus 11 months for male PS19 monogenic). Between male and female bigenic mice, males showed a statistically significant increase in premature death as shown in F (P = 0.0211). n = 32 for PS19 females, n = 44 for PS19 males, n = 24 for PS19;PDAPP females, n = 35 for PS19;PDAPP males.