Figure 4.

MCP-1^−/− BMDCs do not stimulate healing in ischemic limbs. Morphometric analysis of cross-sections of ischemic Lepr^db murine calf muscle treated on the day of femoral artery ligation with vehicle (Veh) or wild-type (C57), TNF-α^−/−, or MCP-1^−/− BMDCs and harvested at day five. Capillary length and muscle volume were computed in a 3.5-mm thick cross section of an anatomically defined region. Measurements were made on five sections at 700-μm intervals. A: Total capillary length of BSLB4-labeled vessels. B: Total volume of healthy muscle. *P < 0.05 relative to Veh and MCP-1^−/−. N = 5 to 9 for each group. Bars = SEM.