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. 2010 Oct;177(4):2002–2010. doi: 10.2353/ajpath.2010.091232

Figure 6.

Figure 6

BMDC-mediated tissue repair is attenuated in mice whose endogenous cells lack MCP-1. A and B: Regression analysis of tissue concentrations of MCP-1 at one day after injury versus capillary length (A) and healthy muscle volume (B) at day five in Leprdb mice treated with vehicle or wild-type (C57), Leprdb, TNF-α−/−, or MCP-1−/− BMDCs. C–F: Morphometric analysis of ischemic calf muscle in mice treated on the day of arterial ligation with vehicle (Veh) or wild-type (C57) BMDCs and harvested at day five. Total capillary length of BSLB4-labeled vessels (C and E) and total healthy muscle volume (D and F) in an anatomically defined region. Measurements were made on five sections at 700 μm intervals. Recipients were MCP-1−/− mice (C and D) and Leprdb mice whose BM of was replaced with BM from MCP-1−/− mice (E and F). *P < 0.05 relative to all groups. N = 3 to 9 per group. Bars = SEM.