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Phase-specific distribution of cell-cycle biomarkers in proliferating cells and out-of-cycle states. Three distinct cell-cycle phenotypes (I, II, and III) are characterized by the differential expression of cell-cycle biomarkers Mcm2, geminin, Plk-1, and histone H3 phosphorylated on Ser-10 (H3S10ph). Prognosis and treatment response can be predicted from the distinct immunoexpression profile displayed by a tumor.15 DFS indicates disease-free survival.
