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. 2010 Oct;177(4):2080–2090. doi: 10.2353/ajpath.2010.100104

Figure 3.

Figure 3

TP53 alleles status in tumors. A: Percentage of tumors with a particular TP53 gene status. 2WT, tumors with two wild-type copies of TP53; 1WT, tumors with one WT copy and a deletion of the other one; 1WT/1MUT, tumors with one WT allele and one mutated allele; 1MUT, tumors with one mutated allele and a deletion of the other one; and 2 MUT, tumors with 2 mutated alleles. Significant Fisher's exact test P value is indicated over brackets. B: Boxplot analysis of TP53 expression in the different groups defined according to TP53 alleles status (real-time PCR). Results for LMS and UPS were similar and thus grouped together. Student's t-test P value is indicated over brackets. C: Boxplot analysis of the alterations number in UPS classified according to their TP53 alleles status. Number of alterations was evaluated according to array-CGH data by the VAMP interface (http://bioinfo.curie.fr/vamp).23 Only UPS data are presented because the LMS series was too small to be really statistically informative. *P < 0.05; **P < 0.01 (Student's t-test) (2WT vs 1WT: P = 1.2.10−6; 2WT vs. 1WT/1MUT: P = 1.4.10−2; 2WT vs. 1or2MUT: P = 2.4.10−3).