Figure 7.

p16 and p15 protein expression in sarcomas. A: Representative p16 and p15 Western blot. β-actin and Ponceau staining, loading controls. B: Examples of p16 immunohistolabeling. Strong positivity, score of 2; positive staining, score of 1; few cells expressing the protein with a weak staining, score of 0.5; and negative staining, score of 0. Scale bar = 40 μm. C: p16 expression scoring repartition in the different TP53 tumor types. p16 immunohistochemistry scores were established as described above. *P < 0.05; **P < 0.01 (Fisher's exact test).