Table 1.
Association between SNPs at 10q23 and 1q22 and risk for gastric cancer in all cases and by anatomic location within the stomach
| Genome-wide phase | Second phase | Combined | ||||||
|---|---|---|---|---|---|---|---|---|
| Cancer group and chromosome location | NCBI dbSNP identifier (major, minor allele) | MAF Controls, Cases combined | P1df score | OR (95%CI) per allele | P1df score | OR (95%CI) per allele | P1df score | OR (95%CI) per allele |
| Total Gastric | Controls/Cases 2100/1625 | Controls/Cases 1202/615 | Controls/Cases 3302/2240 | |||||
| 10q23 | rs2274223 (A, G) | 0.209, 0.259 | 2.33 × 10−9 | 1.40 (1.25–1.56) | 0.12 | 1.15 (0.97–1.36) | 8.40 × 10−9 | 1.31 (1.19–1.43) |
| rs3765524 (C, T) | 0.207, 0.259 | 2.78 × 10−9 | 1.39 (1.25–1.56) | 0.079 | 1.17 (0.98–1.38) | 5.32 × 10−9 | 1.31 (1.20–1.44) | |
| rs3781264 (T, C) | 0.152, 0.199 | 3.94 × 10−11 | 1.51 (1.33–1.70) | 0.40 | 1.09 (0.90–1.31) | 3.76 × 10−9 | 1.36 (1.23–1.50) | |
| rs11187842 (C, T) | 0.147, 0.190 | 3.65 × 10−10 | 1.48 (1.31–1.68) | 0.42 | 1.08 (0.89–1.31) | 2.53 × 10−8 | 1.34 (1.21–1.49) | |
| rs753724 (G, T) | 0.147, 0.190 | 2.65 × 10−10 | 1.49 (1.31–1.68) | 0.51 | 1.07 (0.88–1.30) | 2.74 × 10−8 | 1.34 (1.21–1.49) | |
| 1q22 | rs4072037 (A, G) | 0.159, 0.125 | 1.10 × 10−6 | 0.71 (0.62–0.82) | 0.083 | 0.84 (0.69–1.02) | 4.22 × 10−7 | 0.75 (0.67–0.84) |
| rs4460629 (C, T) | 0.142, 0.112 | 3.37 × 10−7 | 0.68 (0.59–0.79) | 0.34 | 0.91 (0.74–1.11) | 2.26 × 10−6 | 0.75 (0.67–0.85) | |
| Cardia | Controls/Cases 2100/1110 | Controls/Cases 1202/103 | Controls/Cases 3302/1213 | |||||
| 10q23 | rs2274223 (A, G) | 0.209, 0.291 | 5.88 × 10−14 | 1.59 (1.41–1.80) | 0.016 | 1.49 (1.08–2.07) | 4.19 × 10−15 | 1.57 (1.40–1.76) |
| rs3765524 (C, T) | 0.207, 0.289 | 9.94 × 10−14 | 1.59 (1.40–1.79) | 0.014 | 1.50 (1.08–2.08) | 7.36 × 10−15 | 1.56 (1.40–1.75) | |
| rs3781264 (T, C) | 0.152, 0.222 | 7.94 × 10−14 | 1.66 (1.45–1.90) | 0.17 | 1.29 (0.89–1.87) | 1.06 × 10−13 | 1.60 (1.41–1.81) | |
| rs11187842 (C, T) | 0.147, 0.211 | 1.44 × 10−12 | 1.63 (1.42–1.87) | 0.25 | 1.25 (0.86–1.81) | 2.56 × 10−12 | 1.56 (1.38–1.77) | |
| rs753724 (G, T) | 0.147, 0.210 | 1.61 × 10−12 | 1.63 (1.42–1.87) | 0.49 | 1.15 (0.77–1.70) | 5.21 × 10−12 | 1.56 (1.37–1.76) | |
| 1q22 | rs4072037 (A, G) | 0.159, 0.122 | 3.37 × 10−4 | 0.75 (0.65–0.88) | 0.18 | 0.74 (0.48–1.15) | 9.45 × 10−5 | 0.75 (0.65–0.87) |
| rs4460629 (C, T) | 0.142, 0.108 | 1.13 × 10−4 | 0.72 (0.61–0.85) | 0.58 | 0.89 (0.58–1.36) | 1.27 × 10−4 | 0.74 (0.64–0.86) | |
| Noncardia | Controls/Cases 2100/515 | Controls/Cases 1202/402 | Controls/Cases 3302/917 | |||||
| 10q23 | rs2274223 (A, G) | 0.209, 0.221 | 0.78 | 1.02 (0.86–1.22) | 0.34 | 1.10 (0.90–1.35) | 0.44 | 1.05 (0.93–1.20) |
| rs3765524 (C, T) | 0.207, 0.222 | 0.73 | 1.03 (0.87–1.22) | 0.25 | 1.12 (0.92–1.37) | 0.32 | 1.07 (0.94–1.21) | |
| rs3781264 (T, C) | 0.152, 0.171 | 0.094 | 1.18 (0.97–1.42) | 0.60 | 1.06 (0.85–1.33) | 0.14 | 1.11 (0.97–1.29) | |
| rs11187842 (C, T) | 0.147, 0.166 | 0.099 | 1.17 (0.97–1.42) | 0.55 | 1.07 (0.86–1.34) | 0.13 | 1.12 (0.97–1.29) | |
| rs753724 (G, T) | 0.147, 0.167 | 0.070 | 1.19 (0.99–1.44) | 0.53 | 1.08 (0.86–1.35) | 0.098 | 1.13 (0.98–1.30) | |
| 1q22 | rs4072037 (A, G) | 0.159, 0.126 | 7.26 × 10−6 | 0.60 (0.47–0.75) | 0.40 | 0.91 (0.73–1.14) | 5.74 × 10−5 | 0.72 (0.62–0.85) |
| rs4460629 (C, T) | 0.142, 0.115 | 1.53 × 10−5 | 0.59 (0.47–0.75) | 0.79 | 0.97 (0.77–1.22) | 5.38 × 10−4 | 0.75 (0.64–0.88) | |
Minor allele frequencies were computed from the combined phase. Results were derived from logistic regression models using genotype trend tests adjusted for age (10 year categories), sex, and study. The total of 2,240 gastric cancer cases included all cardia and noncardia cancers plus 110 unclassified gastric cancers which were added in the second phase.