Table 2.
Association between SNPs at 22q12and 10q23 and risk for esophageal squamous cell carcinoma
| Genome-wide phase | Second phase | Combined | ||||||
|---|---|---|---|---|---|---|---|---|
| Chromosome location | NCBI dbSNP identifier (major, minor allele) | MAF Controls, Cases combined | P1df score | OR (95%CI) per allele | P1df score | OR (95%CI) per allele | P1df score | OR (95%CI)per allele |
| ESCC | Controls/Cases 2100/1898 | Controls/Cases 1202/217 | Controls/Cases 3302/2115 | |||||
| 10q23 | rs2274223 (A, G) | 0.209, 0.259 | 1.19 × 10−7 | 1.33 (1.20–1.48) | 2.13 × 10−4 | 1.59 (1.24–2.05) | 3.85 × 10−9 | 1.34 (1.22–1.48) |
| rs3765524 (C, T) | 0.207, 0.258 | 9.42 × 10−8 | 1.34 (1.20–1.49) | 6.01 × 10−5 | 1.66 (1.29–2.12) | 1.74 × 10−9 | 1.35 (1.22–1.49) | |
| rs3781264 (T, C) | 0.152, 0.194 | 1.15 × 10−7 | 1.38 (1.22–1.55) | 7.92 × 10−4 | 1.60 (1.21–2.11) | 7.30 × 10−9 | 1.38 (1.23–1.53) | |
| rs11187842 (C, T) | 0.147, 0.187 | 2.67 × 10−7 | 1.37 (1.21–1.54) | 3.91 × 10−4 | 1.64 (1.25–2.17) | 1.20 × 10−8 | 1.37 (1.23–1.53) | |
| rs753724 (G, T) | 0.147, 0.187 | 2.23 × 10−7 | 1.37 (1.22–1.55) | 5.13 × 10−4 | 1.63 (1.24–2.16) | 1.15 × 10−8 | 1.38 (1.23–1.54) | |
| 22q12 | rs738722 (C, T) | 0.254, 0.308 | 5.67 × 10−8 | 1.32 (1.19–1.45) | 0.14 | 1.20 (0.94–1.53) | 1.41 × 10−8 | 1.30 (1.19–1.43) |
Minor allele frequencies were computed from the combined phase. Results were derived from logistic regression models using genotype trend tests adjusted for age (10 year categories), sex, and study.