Table 3.

Summary of validation results.

	Concordance index C*	Observed/Expected O/E ratio†	Mean Squared Error
MelaPRO-HBI	0.86 (0.75, 0.97)	0.85 (0.62, 1.08)	0.06 (0.03, 0.08)
MelaPRO-LBI	0.86 (0.74, 0.97)	0.31 (0.20, 0.42)	0.19 (0.15, 0.22)
MelaPRO-GEM	0.83 (0.67, 0.98)	0.54 (0.38, 0.72)	0.08 (0.06, 0.11)
MELPREDICT‡	0.82 (0.61, 0.93)	1.10 (0.92, 1.17)	0.09 (0.04, 0.12)
Difference Between MelaPRO-HBI and MelaPRO-LBI	0.007 (−0.01,0.02)	Not Applicable§	−0.13 (−0.16, −0.10)
Difference Between MelaPRO-HBI and MelaPRO-GEM	0.04 (−0.008, 0.09)	Not Applicable	−0.03 (−0.04, −0.02)
Difference Between MelaPRO-HBI and MELPREDICT	0.05 (0.007, 0.17)	Not Applicable	−0.03 (−0.06, 0.002)
	Sensitivity	Specificity
FH:≥2 affected relatives	0.81	0.58

^*The concordance index C is equal to the AUC (area under the ROC curve)

^†The ratio between the observed number of carriers and the total number of predicted carriers

^‡Leave-one-out cross-validation on Boston data using fixed covariates for MELPREDICT

^§Computing the difference in this case is not appropriate, as each ratio should be compared to the reference value of one.