Figure 11.

Variation of protein noise with mean abundance. From an asynchronous population of mother and daughter cells, we picked a sample of cells from a narrow range of volumes around the mean cell size (mean±1 fL). This procedure mimics the ‘gating’ method that Newman et al (2006) used to reduce extrinsic noise. We calculated the mean and coefficient of variation of every protein in this sample of cells. For proteins with multiple phospho-forms (SBF, Whi5, Cdh1 and Net1) and/or bound in complexes (Cdc14, Net1, SBF and Whi5), we computed the mean and CV for the total population of each protein. We include data for haploid, diploid and tetraploid cells in the same plot.