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. Author manuscript; available in PMC: 2011 Sep 21.

Published in final edited form as: Biochemistry. 2010 Sep 21;49(37):8094–8104. doi: 10.1021/bi100879m

Fig. 3 — Overlay of the three structures showing the divergence in the positions of R1 or R2 groups. A. In this stereoview of the superimposed active sites, the imipenem complex is colored yellow, the cloxacillin complex is blue and the cefoxitin complex is green. For clarity, atoms of the β-lactams have been rendered with a degree of transparency. Note the conservation of the hydrogen bonding network, shown as dashed lines. B. The same overlay, but showing only the three antibiotics. The arrow marks the position of the ring nitrogen.

Fig. 3 — Overlay of the three structures showing the divergence in the positions of R1 or R2 groups. A. In this stereoview of the superimposed active sites, the imipenem complex is colored yellow, the cloxacillin complex is blue and the cefoxitin complex is green. For clarity, atoms of the β-lactams have been rendered with a degree of transparency. Note the conservation of the hydrogen bonding network, shown as dashed lines. B. The same overlay, but showing only the three antibiotics. The arrow marks the position of the ring nitrogen.