. Author manuscript; available in PMC: 2011 Sep 21.

Published in final edited form as: Biochemistry. 2010 Sep 21;49(37):8094–8104. doi: 10.1021/bi100879m

Table 2.

Lack of correlation between enzyme-β-lactam complementarity and second order rate of acylation

Antibiotic	Total area difference (Å²)	Non- covalent interaction energy (kcal/mol)^*	k₂/K_S (M⁻¹/sec⁻¹)^*
Imipenem	166	2.6 ± 0.4	790 ± 170
cloxacillin	258	2.7 ± 0.2	104 ± 30
cefoxitin	193	2.0 ± 0.4	2750 ± 590

data from (12)