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. 2010 Jul 21;19(20):3983–3994. doi: 10.1093/hmg/ddq313

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Figure 1. — Generation of cloned HD transgenic pigs. (A) DNA construct for expression of transgenic N-terminal mutant htt (N208-105Q or N208-160Q). CAG: the cytomegalovirus enhancer and chicken beta-actin promoter. (B) PCR analysis of the CAG repeats (105 and 160) in transgenic htt in pig fibroblast cell clones. (C) Expression of transgenic htt (N208-105Q) and ECFP in cloned Tibetan miniature pig fibroblast cells. (D) PCR reveals the presence of transgenic htt in tail tissues of all cloned transgenic pigs. (E) A live Tibetan miniature pig (7-1-3) transgenic for N208-105Q htt at 10 days after birth. (F) Expression of transgenic ECFP in cultured cells isolated from transgenic HD pigs (7-9 and 7-1-3).